Analytical Instruments & Bioanalysis
analytical_instruments_bioanalysis.doc | |
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Course Description
This course provides an introduction to the fundamental principles of chemical measurement used in medical diagnosis, quality assurance and control, and research studies. We will focus on understanding the fundamental principles underlying instrumental methods and their realization in modern instrumentation for analysis.
The students will survey the theory and application of instruments such as: visible, ultra violet, Infra red, Fluorescence, Nuclear Magnetic Resonance, Atomic absorption, Chromatography, blood gas analyzer, cell counter, and Mass Spectrometry.
This is not a "how-to" course; you will not learn how to operate analytical instruments nor will we cover specific analytical "recipes;" these change (sometimes quite quickly) with time as the discipline grows, so our focus on principles and concepts of implementation should provide greater insight both into how current instruments work as well as the basis for your understanding how they will work a decade from now.
The students will survey the theory and application of instruments such as: visible, ultra violet, Infra red, Fluorescence, Nuclear Magnetic Resonance, Atomic absorption, Chromatography, blood gas analyzer, cell counter, and Mass Spectrometry.
This is not a "how-to" course; you will not learn how to operate analytical instruments nor will we cover specific analytical "recipes;" these change (sometimes quite quickly) with time as the discipline grows, so our focus on principles and concepts of implementation should provide greater insight both into how current instruments work as well as the basis for your understanding how they will work a decade from now.
Course Learning Objectives
At the end of the semester the student is able to:
1. Appreciate the connectivity between math, physics, chemistry, and biology in this course. (Program Outcome a).
2. Demonstrate mathematical and basic computer skills, and discover the impact of science and technology. (Program Outcome a, k, h).
3. Understand the proper use and importance of measurement statistics. (Program Outcome b).
4. Understand the theory and design of the instrumental instruments. (Program Outcome c).
5. Understand how the instrument actually makes the measurement. (Program Outcome c).
6. Work with his group in any clinical laboratory to complete the project.(Program Outcome d)
7. Uses ethical conduct in communication (using citations, acknowledging sources of info). (Program Outcome f).
8. Conveys information effectively in written and oral presentations. (Program Outcome g).
9. Understand and appreciate the role of instruments in solving problems in the physical, chemical and biological sources. (Program Outcome h).
10. Develop an understanding of the analytical capabilities of a number of instrumental methods. (Program Outcome k).
11. Search pertinent, professional literature, use other information resources and evaluate how sources contribute to knowledge. (Program Outcome i)
12. Understand the chemical and/or physical principles exploited during the measurement. (Program Outcome j).
13. Understand the theoretical concepts behind each instrument. (Program Outcome j).
14. Operate, manipulate, and generate data for each instrument. (Program Outcome j).
15. Solve chemical problems quantitatively and qualitatively by making appropriate choices among the various instruments. (Program Outcome k).
16. Appreciate the complexity of each instrument, its strength, and its limitation. (Program Outcome k).
17. Explore the use of Internet (Netscape) as an educational source in instrumentation. (Program Outcome k).
1. Appreciate the connectivity between math, physics, chemistry, and biology in this course. (Program Outcome a).
2. Demonstrate mathematical and basic computer skills, and discover the impact of science and technology. (Program Outcome a, k, h).
3. Understand the proper use and importance of measurement statistics. (Program Outcome b).
4. Understand the theory and design of the instrumental instruments. (Program Outcome c).
5. Understand how the instrument actually makes the measurement. (Program Outcome c).
6. Work with his group in any clinical laboratory to complete the project.(Program Outcome d)
7. Uses ethical conduct in communication (using citations, acknowledging sources of info). (Program Outcome f).
8. Conveys information effectively in written and oral presentations. (Program Outcome g).
9. Understand and appreciate the role of instruments in solving problems in the physical, chemical and biological sources. (Program Outcome h).
10. Develop an understanding of the analytical capabilities of a number of instrumental methods. (Program Outcome k).
11. Search pertinent, professional literature, use other information resources and evaluate how sources contribute to knowledge. (Program Outcome i)
12. Understand the chemical and/or physical principles exploited during the measurement. (Program Outcome j).
13. Understand the theoretical concepts behind each instrument. (Program Outcome j).
14. Operate, manipulate, and generate data for each instrument. (Program Outcome j).
15. Solve chemical problems quantitatively and qualitatively by making appropriate choices among the various instruments. (Program Outcome k).
16. Appreciate the complexity of each instrument, its strength, and its limitation. (Program Outcome k).
17. Explore the use of Internet (Netscape) as an educational source in instrumentation. (Program Outcome k).
Course Textbooks
Principles of Instrumental Analysis, Sixth Edition by: Douglas A. Skoog, F. James Holler, Stanley R. Crouch Password: ebooksclub.org
Undergraduate Instrumental Analysis, Sixth Edition,James W. Robinson,2004
Other resources:
(1) The Biomedical Engineering Handbook, 3rd Edition (3 Volume Set)by: Joseph D. Bronzino (2) Encyclopedia of Medical Devices and Instrumentation, 6 Volume Set - Second Edition by: John G. Webster Part1 Part2 Part3 Part4 Password: rafcm
Ewing's Analytical Instrumentation Handbook, Third Edition, Jack Cazes, 2009
Introduction to biomedical equipment technology, Joseph Carr, 1998
Encyclopedia of Medical Devices and Instrumentation, 6 Volume Set - Second Edition by: John G. Webster
The Biomedical Engineering Handbook, 3rd Edition (3 Volume Set) by: Joseph D. Bronzino
Medical Instrumentation Application and Design, 4th Edition by: John G. Webster
Handbook of Modern Sensors: Physics, Designs, and Applications, Fourth Edition by: Jacob Fraden
Biomedical Instrumentation: Technology and Applications By R. Khandpur
Undergraduate Instrumental Analysis, Sixth Edition,James W. Robinson,2004
Other resources:
(1) The Biomedical Engineering Handbook, 3rd Edition (3 Volume Set)by: Joseph D. Bronzino (2) Encyclopedia of Medical Devices and Instrumentation, 6 Volume Set - Second Edition by: John G. Webster Part1 Part2 Part3 Part4 Password: rafcm
Ewing's Analytical Instrumentation Handbook, Third Edition, Jack Cazes, 2009
Introduction to biomedical equipment technology, Joseph Carr, 1998
Encyclopedia of Medical Devices and Instrumentation, 6 Volume Set - Second Edition by: John G. Webster
The Biomedical Engineering Handbook, 3rd Edition (3 Volume Set) by: Joseph D. Bronzino
Medical Instrumentation Application and Design, 4th Edition by: John G. Webster
Handbook of Modern Sensors: Physics, Designs, and Applications, Fourth Edition by: Jacob Fraden
Biomedical Instrumentation: Technology and Applications By R. Khandpur
Course slides:
Lecture presentation of January 22, 2012 Introduction to Medical Laboratory Instruments
l1_introduction_to_the_course.ppt | |
File Size: | 1903 kb |
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Lecture presentation of January 05, 2012 Introduction to Spectroscopy
l2_introduction_to_spectroscopy.pptx | |
File Size: | 1625 kb |
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Lecture presentation of February 12, 2012 Sources of noise in instrumental analysis
l3_sources_of_noise_in_instrumental_analysis.pptx | |
File Size: | 1718 kb |
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Lecture presentation of February 19 2012 Beer Law From the text
Lecture of February 26+ March 4, 2012 Spectrophotometer
spectrophotometer.pptx | |
File Size: | 1799 kb |
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Lecture Code of March 11, 2012 Blood cell counter + Blood Gas Analyzer
l5_cell_counter.pptx | |
File Size: | 544 kb |
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l8_blood_gas_analyzer.pptx | |
File Size: | 2305 kb |
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Course Sheet
sheet.pdf | |
File Size: | 244 kb |
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Course Exam
2010-2011 Midterm Exam
midterm_answersa.pdf | |
File Size: | 44 kb |
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Course Labs: TBA
Grading Policy
Term Exam: 60 points
Midterm Exam: 15 Points
Project: 15 Points
Other (Homework assignments, quizzes, etc.): 10 points
Grade will be the summation of all of the above weighted by your attendance percentage. Failing to attend at least 80% of the classes will result in a failing grade in this class.
Midterm Exam: 15 Points
Project: 15 Points
Other (Homework assignments, quizzes, etc.): 10 points
Grade will be the summation of all of the above weighted by your attendance percentage. Failing to attend at least 80% of the classes will result in a failing grade in this class.
Course Project
Students will be organized into teams of four and each team search for the principle of operation of instruments which exist in the clinical laboratory.
The team should share and distribute responsibility. Each team submits a technical report and prepares a class presentation. Making use of all resources, e.g., patents, journal publications, internet, labs, etc., is encouraged. The PROJECT is due on 18/03/2012. The report must be typed. Hand-written reports are not accepted. Late reports are not accepted.
A group presentation on the topic and each member of the group should be involved in the presentation of the topic. The presentation will be presented during approximately 15 minutes for each presentation.
Deadline is 18/03/2012
The team should share and distribute responsibility. Each team submits a technical report and prepares a class presentation. Making use of all resources, e.g., patents, journal publications, internet, labs, etc., is encouraged. The PROJECT is due on 18/03/2012. The report must be typed. Hand-written reports are not accepted. Late reports are not accepted.
A group presentation on the topic and each member of the group should be involved in the presentation of the topic. The presentation will be presented during approximately 15 minutes for each presentation.
Deadline is 18/03/2012
Oral Presentation Grading:
Criteria Points
Organization 2
Clarity of presentation 2
Effectiveness 2
Technical Accuracy & grasp of the subject 2
Engineering versus biology content 2
Total 10
Criteria Points
Organization 2
Clarity of presentation 2
Effectiveness 2
Technical Accuracy & grasp of the subject 2
Engineering versus biology content 2
Total 10
Useful Links
http://www.chem.ufl.edu/~cao/chm4130/Lectures.html
http://loer.tamug.edu/Loup/MARS450/MARS450.htm
http://www.cem.msu.edu/~cem333/LectureMenu.html
http://www.hitachi-hitec.com/global/science/uv_vis/uv_basic_2.html
http://www.shsu.edu/~chm_tgc/primers/spect.html
http://its.uvm.edu/ee227/
http://cires.colorado.edu/jimenez/CHEM-4181/
http://www.chem.utoronto.ca/coursenotes/CHM217
Animations in an Instrumental Methods Chemistry Class
http://www.stfrancis.edu/content/ns/diab/instrum.htm
http://loer.tamug.edu/Loup/MARS450/MARS450.htm
http://www.cem.msu.edu/~cem333/LectureMenu.html
http://www.hitachi-hitec.com/global/science/uv_vis/uv_basic_2.html
http://www.shsu.edu/~chm_tgc/primers/spect.html
http://its.uvm.edu/ee227/
http://cires.colorado.edu/jimenez/CHEM-4181/
http://www.chem.utoronto.ca/coursenotes/CHM217
Animations in an Instrumental Methods Chemistry Class
http://www.stfrancis.edu/content/ns/diab/instrum.htm